Summary Report on Course #1 - Introduction to the Mathematics of Biological Complexity - in the series of Short Courses on the Mathematics of Biological Complexity Supported by National Institutes of Health Award GM59924-01 The University of Tennessee Conference Center June 11-14, 2000 June 21, 2000 Course Director: Louis J. Gross, University of Tennessee Lecturers: Stephen P. Ellner, North Carolina State University Denise Kirschner, University of Michigan This course included 23 lectures and 8 computer lab sessions devoted to deterministic and stochastic mathematical approaches used in many areas of the life sciences. Topics were covered rapidly with emphasis on a conceptual framework for understanding applications with particular emphasis on population biology, genetics, immunology, and epidemiology examples. The target audience were individuals with little formal mathematics training beyond calculus. Topics covered included: objectives of modeling, birth and death processes, branching processes, matrix models, ordinary and partial differential equation models, branching processes, and discrete dynamical system models. The complete schedule as well as many of the lecture and lab materials are available at http://www.tiem.utk.edu/courses/course1.html. There were a total of 37 participants, including the three lecturers. Participants educational backgrounds: 16 Ph.D.-level scientists (7 faculty members, 3 post-doctoral associates at universities, and 6 staff members from various organizations including the Smithsonian, NIST, ORNL and USGS), 1 M.D., 13 graduate students and 4 undergraduate students. The faculty in attendance were from life science or chemistry departments, and all the graduate students in attendance are pursuing degrees in a variety of life science disciplines. The undergraduates, all of whom are entering senior year, are completing degrees in biology or joint degrees in biology and math. The 8 computer labs associated with the course used the software packages Maple, Matlab and Ecobeaker. The labs included stochastic process simulation, ordinary differential equation models for epidemics (emphasizing HIV), matrix population models, spatial simulations, and population viability analysis. All activities were held in the facilities of the UT Conference Center and all participants were provided meals together in order to foster interactions outside of the formal lectures and labs. An anonymous evaluation was conducted immediately following the conclusion of the course, with 26 respondents. The questions and a summary of responses follows. 1. Was this worth attending - if you knew before attending what you know now about the course topics and coverage, would you have chosen to attend? Yes 26 No 0 2. Did the topic coverage meet your expectations? Yes 22 No 0 Partially 4 If you answered other than Yes, what topics did you expect to be covered that were not? Relatedness and selection models Chaos and complexity Biocomplexity Toxicology 3. What topics covered were of most interest to you? Every topic was mentioned, with Markov chains, matrix models and differential equation models being mentioned more than other topics. 4. Were the computer labs generally worth the time or would you have preferred the time be spent on: Worth the time 24 Would have preferred the time spent on: 1. Workshops sessions based upon problems brought by participants 1 2. More lectures or longer lectures 3. Roundable discussion sessions 1 4. Other (please state) 5. The meals were: Excellent 20 Good 6 Fair 0 Poor 0 6. The hotel was: Excellent 9 Good 11 Fair 2 Poor 0